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KMID : 1004820140150020068
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Journal of Biomedical Research
2014 Volume.15 No. 2 p.68 ~ p.71
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Association between carotid intima-media thickness and Ankle-Brachial Index in patients with ischemic stroke
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Yoon Young-Mi
Lee Hyung-Suk
Baek Shin-Hye
Lee Hye-Lim
Yeo Min-Ju
Choi Seo-Young
Kim Ji-Seon
Lee Sung-Hyun
Lee Sang-Soo
Shin Dong-Ick
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Abstract
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Background and Purpose: The Ankle-Brachial Index (ABI) is the ratio of blood pressure in the lower legs to that in the arms. The intima-media thickness (IMT) of extracranial carotid arteries determined by B-mode ultrasound is a measurable index of the presence of atherosclerosis. A low ABI and a high carotid IMT are independently related to increased risk of cardiovascular events. This study examined the association between carotid IMT and ABI in patients with ischemic stroke.
Materials and Methods: Retrospectively, 116 hospitalized patients with ischemic stroke were recruited. Using a pulse wave velocity ABI device along with carotid duplex sonography, we measured carotid IMT and ABI and investigated the correlation between average values.
Results: There was a significant difference in carotid IMT between the normal and abnormal ABI groups (P=0.0262). The group with an abnormal ABI was more than five times as likely to have increased carotid IMT as the group with a normal ABI (age, sex-adjusted OR 5.67 (95% CI 1.85~17.38)). The ABI and carotid IMT showed a weak inverse linear correlation in patients with ischemic stroke (correlation coefficient ?0.378 after adjusting for age and sex).
Conclusion: Our study suggests that an abnormal ABI is associated with a high carotid IMT in patients with ischemic stroke.
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KEYWORD
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ischemic stroke, carotid, intima media thickness, ankle brachial index, atherosclerosis
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